Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice

High concentrations of nitric oxide (NO) cause DNA damage and apoptosis in many cell types. Thus, regulation of NO synthase (NOS) activity is essential for minimizing effects of cytotoxic and genotoxic nitrogen oxide species. We have shown previously that NO-induced p53 protein accumulation down-reg...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ambs, Stefan, Ogunfusika, Mofolusara O., Merriam, William G., Bennett, William P., Billiar, Timothy R., Harris, Curtis C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21161/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671763/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8823
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