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Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins

Organelle acidification plays a demonstrable role in intracellular protein processing, transport, and sorting in animal cells. We investigated the relationship between acidification and protein sorting in yeast by treating yeast cells with ammonium chloride and found that this lysosomotropic agent c...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1989
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2115461/
https://ncbi.nlm.nih.gov/pubmed/2526133
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