Signaling pathways in Ras-mediated tumorigenicity and metastasis

The effector domain mutants of oncogenic Ras, V12S35 Ras, V12G37 Ras, and V12C40 Ras were tested for their abilities to mediate tumorigenic and metastatic phenotypes in athymic nude mice when expressed in NIH 3T3 fibroblasts. All mutants displayed comparable tumorigenic properties, but only the muta...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Webb, Craig P., Van Aelst, Linda, Wigler, Michael H., Vande Woude, George F.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1998
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671754/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8773
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