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Suppression of NF-κB-mediated β-defensin gene expression in the mammalian airway by the Bordetella type III secretion system
Expression of innate immune genes such as β-defensins is induced in airway epithelium by bacterial components via activation of NF-κB. We show here that live Gram-negative bacteria can similarly stimulate this pathway, resulting in upregulation of the β-defensin tracheal antimicrobial peptide (TAP)...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2111170/ https://ncbi.nlm.nih.gov/pubmed/15760449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2004.00473.x |
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