The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

We report here the reconstitution of a pathway that leads to the apoptotic changes in nuclei by using recombinant DNA fragmentation factor (DFF), a heterodimeric protein of 40 and 45 kDa. Coexpression of DFF40 and DFF45 is required to generate recombinant DFF, which becomes activated when DFF45 is c...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Xuesong, Li, Peng, Widlak, Piotr, Zou, Hua, Luo, Xu, Garrard, William T., Wang, Xiaodong
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21098/
https://ncbi.nlm.nih.gov/pubmed/9671700
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