Substitution of a pentalenolactone-sensitive glyceraldehyde-3-phosphate dehydrogenase by a genetically distinct resistant isoform accompanies pentalenolactone production in Streptomyces arenae.

Pentalenolactone (PL), an antibiotic produced by Streptomyces arenae, is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The producer strain contains different isoforms of GAPDH: a PL-sensitive enzyme on nonproduction media and a PL-insensitive enzyme on production media. Aft...

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Εκδόθηκε σε:	J Bacteriol
Κύριοι συγγραφείς:	Fröhlich, K U, Wiedmann, M, Lottspeich, F, Mecke, D
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1989
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC210565/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2592349/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.171.12.6696-6702.1989
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