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Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2
O-glycan biosynthesis is initiated by the transfer of N-acetylgalactosamine (GalNAc) from a nucleotide-sugar donor (UDP-GalNAc) to Ser/Thr residues of an acceptor substrate. The detailed transfer mechanism, catalyzed by the UDP-GalNAc polypeptide:N-acetyl-α-galactosaminyltransferases (ppGalNAcTs), r...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2100437/ https://ncbi.nlm.nih.gov/pubmed/17850816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.08.028 |
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