Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2

O-glycan biosynthesis is initiated by the transfer of N-acetylgalactosamine (GalNAc) from a nucleotide-sugar donor (UDP-GalNAc) to Ser/Thr residues of an acceptor substrate. The detailed transfer mechanism, catalyzed by the UDP-GalNAc polypeptide:N-acetyl-α-galactosaminyltransferases (ppGalNAcTs), r...

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Bibliographic Details
Main Authors: Milac, A. L., Buchete, N. V., Fritz, T. A., Hummer, G., Tabak, L. A.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2100437/
https://ncbi.nlm.nih.gov/pubmed/17850816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.08.028
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