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Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague Dawley rats and effects of data normalization methods on statistical and quantitative analysis

BACKGROUND: Urine from male Sprague-Dawley rats 25, 40, and 80 days old was analyzed by NMR and UPLC/MS. The effects of data normalization procedures on principal component analysis (PCA) and quantitative analysis of NMR-based metabonomics data were investigated. Additionally, the effects of age on...

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Main Authors: Schnackenberg, Laura K, Sun, Jinchun, Espandiari, Parvaneh, Holland, Ricky D, Hanig, Joseph, Beger, Richard D
格式: Artigo
語言:Inglês
出版: BioMed Central 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099495/
https://ncbi.nlm.nih.gov/pubmed/18047726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-8-S7-S3
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