Nanopore current transduction analysis of protein binding to non-terminal and terminal DNA regions: analysis of transcription factor binding, retroviral DNA terminus dynamics, and retroviral integrase-DNA binding

BACKGROUND: Synthetic transcription factors (STFs) promise to offer a powerful new therapeutic against Cancer, AIDS, and genetic disease. Currently, 10% of drugs are of this type, including salicylate and tamoxifen. STFs that can appropriately target (and release) their transcription factor binding...

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Autors principals: Winters-Hilt, Stephen, Davis, Amanda, Amin, Iftekhar, Morales, Eric
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
Matèries:
Proceedings
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099478/
https://ncbi.nlm.nih.gov/pubmed/18047709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-8-S7-S10
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