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Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1

The transcription repressor Bach1 is a sensor and effector of heme that regulates the expression of heme oxygenase 1 and globin genes. Heme binds to Bach1, inhibiting its DNA binding activity and inducing its nuclear export. We found that hemin further induced the degradation of endogenous Bach1 in...

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Detaylı Bibliyografya
Asıl Yazarlar: Zenke-Kawasaki, Yukari, Dohi, Yoshihiro, Katoh, Yasutake, Ikura, Tsuyoshi, Ikura, Masae, Asahara, Toshimasa, Tokunaga, Fuminori, Iwai, Kazuhiro, Igarashi, Kazuhiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099246/
https://ncbi.nlm.nih.gov/pubmed/17682061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02415-06
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