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Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1
The transcription repressor Bach1 is a sensor and effector of heme that regulates the expression of heme oxygenase 1 and globin genes. Heme binds to Bach1, inhibiting its DNA binding activity and inducing its nuclear export. We found that hemin further induced the degradation of endogenous Bach1 in...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2099246/ https://ncbi.nlm.nih.gov/pubmed/17682061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02415-06 |
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