Disruption of lysosomal targeting is associated with insecticidal potency of juvenile hormone esterase

Juvenile hormone esterase (JHE; EC 3.1.1.1), which is intrinsically involved in regulation of development of some insect larvae, is rapidly removed from the hemolymph by the pericardial cells. Lys-29 and Lys-524, which are implicated in the degradation of JHE, were mutated to Arg. Neither the half-l...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Bonning, Bryony C., Ward, Vernon K., van Meer, Marnix M. M., Booth, Tim F., Hammock, Bruce D.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Physical Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20991/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9177159/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.12.6007
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