Downregulation of CD94/NKG2A inhibitory receptors on CD8(+ )T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts

The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8(+ )T lymphocytes. Abnormal upregulation of the CD94/NKG2A inhibitory NKR on c...

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Detalhes bibliográficos
Main Authors: Zeddou, Mustapha, Rahmouni, Souad, Vandamme, Arnaud, Jacobs, Nathalie, Frippiat, Frédéric, Leonard, Philippe, Schaaf-Lafontaine, Nicole, Vaira, Dolores, Boniver, Jacques, Moutschen, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2098781/
https://ncbi.nlm.nih.gov/pubmed/17927817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-72
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