Human autoantibodies specific for the α(1A) calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons

The pharmacological properties of voltage-dependent calcium channel (VDCC) subtypes appear mainly to be determined by the α(1) pore-forming subunit but, whether P-and Q-type VDCCs are encoded by the same α(1) gene presently is unresolved. To investigate this, we used IgG antibodies to presynaptic VD...

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Detalhes bibliográficos
Main Authors: Pinto, Ashwin, Gillard, Samantha, Moss, Fraser, Whyte, Kathryn, Brust, Paul, Williams, Mark, Stauderman, Ken, Harpold, Michael, Lang, Bethan, Newsom-Davis, John, Bleakman, David, Lodge, David, Boot, John
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20975/
https://ncbi.nlm.nih.gov/pubmed/9653186
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