Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y(12) receptor and is correlated with protein expression of P2Y(12)

Two ADP receptors have been identified on human platelets: P2Y(1) and P2Y(12). The P2Y(12) receptor blocker clopidogrel is widely used to reduce the risks in acute coronary syndromes, but, currently, there is no P2Y(1) blocker in clinical use. Evidence for variable responses to clopidogrel has been...

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Bibliographic Details
Main Authors: Braun, Oscar Ö, Amisten, Stefan, Wihlborg, Anna-Karin, Hunting, Karen, Nilsson, David, Erlinge, David
Format: Artigo
Language:Inglês
Published: Kluwer Academic Publishers 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096644/
https://ncbi.nlm.nih.gov/pubmed/18404433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-006-9028-9
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