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Late Endosomal Traffic of the Epidermal Growth Factor Receptor Ensures Spatial and Temporal Fidelity of Mitogen-activated Protein Kinase Signaling

Mitogen-activated protein kinase (MAPK) signaling is regulated by assembling distinct scaffold complexes at the plasma membrane and on endosomes. Thus, spatial resolution might be critical to determine signaling specificity. Therefore, we investigated whether epidermal growth factor receptor (EGFR)...

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Autori principali: Taub, N., Teis, D., Ebner, H. L., Hess, M. W., Huber, L. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096590/
https://ncbi.nlm.nih.gov/pubmed/17881733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-02-0098
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