The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′-triiodothyronine (T3) concentration, cold-expo...

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Publicado en:	J Clin Invest
Autores principales:	de Jesus, Lucia A., Carvalho, Suzy D., Ribeiro, Mirian O., Schneider, Mark, Kim, Sung-Woo, Harney, John W., Larsen, P. Reed, Bianco, Antonio C.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 2001
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209445/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11696583/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13803
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