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Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus

Status epilepticus (SE) is a life-threatening neurological disorder associated with a significant morbidity and mortality. Benzodiazepines are the initial drugs of choice for the treatment of SE. Despite aggressive treatment, over 40% of SE cases are refractory to the initial treatment with two or m...

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Autors principals: Deshpande, Laxmikant S., Blair, Robert E., Nagarkatti, Nisha, Sombati, Sompong, Martin, Billy R., DeLorenzo, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094113/
https://ncbi.nlm.nih.gov/pubmed/17289026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2007.01.001
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