Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

The immortalization of human cells is a critical step in multistep carcinogenesis. Oral-esophageal carcinomas, a model system to investigate molecular mechanisms underlying squamous carcinogenesis, frequently involve cyclin D1 overexpression and inactivation of the p53 tumor suppressor. Therefore, o...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Opitz, Oliver G., Suliman, Yasir, Hahn, William C., Harada, Hideki, Blum, Hubert E., Rustgi, Anil K.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11544278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11909
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