Avoidance of stimulation improves engraftment of cultured and retrovirally transduced hematopoietic cells in primates

Recent reports suggest that cells in active cell cycle have an engraftment defect compared with quiescent cells. We used nonhuman primates to investigate this finding, which has direct implications for clinical transplantation and gene therapy applications. Transfer of rhesus CD34(+) cells to cultur...

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Pubblicato in:	J Clin Invest
Autori principali:	Takatoku, Masaaki, Sellers, Stephanie, Agricola, Brian A., Metzger, Mark E., Kato, Ikunoshin, Donahue, Robert E., Dunbar, Cynthia E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209360/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11489938/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12593
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