Automated high resolution optical mapping using arrayed, fluid-fixed DNA molecules

New mapping approaches construct ordered restriction maps from fluorescence microscope images of individual, endonuclease-digested DNA molecules. In optical mapping, molecules are elongated and fixed onto derivatized glass surfaces, preserving biochemical accessibility and fragment order after enzym...

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Détails bibliographiques
Auteurs principaux: Jing, Junping, Reed, Jason, Huang, John, Hu, Xinghua, Clarke, Virginia, Edington, Joanne, Housman, Dan, Anantharaman, Thomas S., Huff, Edward J., Mishra, Bud, Porter, Brett, Shenker, Alexander, Wolfson, Estarose, Hiort, Catharina, Kantor, Ron, Aston, Christopher, Schwartz, David C.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1998
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC20926/
https://ncbi.nlm.nih.gov/pubmed/9653137
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