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Poxvirus DNA topoisomerase knockout mutant exhibits decreased infectivity associated with reduced early transcription
Vaccinia virus encodes a type I DNA topoisomerase that is highly conserved in all known poxviruses. Although the structure and catalytic activity of the enzyme were well studied, little was known about its biological function. The viral topoisomerase was thought to be essential, and roles in DNA rep...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC208750/ https://ncbi.nlm.nih.gov/pubmed/12972642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1534874100 |
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