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Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus

We sought to determine whether intramuscular injection of a recombinant adeno-associated virus (rAAV) vector expressing human factor IX (hF.IX) could direct expression of therapeutic levels of the transgene in experimental animals. High titer (10(12)–10(13) vector genomes/ml) rAAV expressing hF.IX w...

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Bibliografiske detaljer
Main Authors: Herzog, Roland W., Hagstrom, J. Nathan, Kung, Szu-Hoo, Tai, Shing Jen, Wilson, James M., Fisher, Krishna J., High, Katherine A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20861/
https://ncbi.nlm.nih.gov/pubmed/9159155
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