Solution Conformation of Wild-Type and Mutant IgG3 and IgG4 Immunoglobulins Using Crystallohydrodynamics: Possible Implications for Complement Activation

We have employed the recently described crystallohydrodynamic approach to compare the time-averaged domain orientation of human chimeric IgG3wt (wild-type) and IgG4wt as well as two hinge mutants of IgG3 and an IgG4S331P (mutation from serine to proline at position 331, EU numbering) mutant of IgG4....

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Detalhes bibliográficos
Main Authors: Lu, Yanling, Harding, Stephen E., Michaelsen, Terje E., Longman, Emma, Davis, Kenneth G., Ortega, Álvaro, Grossmann, J. Günter, Sandlie, Inger, García de la Torre, José
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2007
Assuntos:
Biophysical Theory and Modeling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084252/
https://ncbi.nlm.nih.gov/pubmed/17704171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.108993
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