RESPONSE TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) DIFFERS IN MOUSE STRAINS AND REVEALS A DIVERGENCE IN JNK SIGNALING AND COX-2 INDUCTION PRIOR TO LOSS OF NEURONS IN THE SUBSTANTIA NIGRA PARS COMPACTA

Parkinson's disease (PD) is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. Recent studies have described the activation of a stress-induced signal cascade, c-Jun N-terminal kinase (JNK)-mediated activation of c-...

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Bibliographische Detailangaben
Hauptverfasser: Boyd, Justin D., Jang, Haeman, Shepherd, Kennie R., Faherty, Ciaran, Slack, Sally, Jiao, Yun, Smeyne, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084084/
https://ncbi.nlm.nih.gov/pubmed/17884023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.07.067
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