Enantioselective Liquid Chromatography – Mass Spectrometry Assay for the Determination of Ifosfamide and Identification of the N-Dechloroethylated Metabolites of Ifosfamide in Human Plasma

A sensitive and specific liquid chromatography-mass spectrometry (LC-MS) method has been developed and validated for the enantioselective determination of ifosfamide [(R)-IF and (S)-IF] in human plasma and for the detection of the N-dechloroethylated metabolites of IF, 2-N-dechloroethylifosfamide [(...

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Autori principali: Oliveira, Regina V., Onorato, Joelle M., Siluk, Danuta, Walko, Christine M., Lindley, Celeste, Wainer, Irving W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2083559/
https://ncbi.nlm.nih.gov/pubmed/17855037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2007.07.026
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