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Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

Zinc-finger proteins of the Cys(2)-His(2) type represent a class of malleable DNA-binding proteins that may be selected to bind diverse sequences. Typically, zinc-finger proteins containing three zinc-finger domains, like the murine transcription factor Zif268 and the human transcription factor Sp1,...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Liu, Qiang, Segal, David J., Ghiara, Jayant B., Barbas, Carlos F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20811/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159105/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5525
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