Peroxiredoxin 6 is required for blood vessel integrity in wounded skin

Peroxiredoxin 6 (Prdx6) is a cytoprotective enzyme with largely unknown in vivo functions. Here, we use Prdx6 knockout mice to determine its role in UV protection and wound healing. UV-mediated keratinocyte apoptosis is enhanced in Prdx6-deficient mice. Upon skin injury, we observe a severe hemorrha...

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Detalhes bibliográficos
Main Authors: Kümin, Angelika, Schäfer, Matthias, Epp, Nikolas, Bugnon, Philippe, Born-Berclaz, Christiane, Oxenius, Annette, Klippel, Anke, Bloch, Wilhelm, Werner, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080929/
https://ncbi.nlm.nih.gov/pubmed/18025307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706090
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