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Molecular imaging of membrane interfaces reveals mode of β-glucosidase activation by saposin C
Acid β-glucosidase (GCase) is a soluble lysosomal enzyme responsible for the hydrolysis of glucose from glucosylceramide and requires activation by the small nonenzymatic protein saposin C (sapC) to gain access to the membrane-embedded glycosphingolipid substrate. We have used in situ atomic force m...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2077267/ https://ncbi.nlm.nih.gov/pubmed/17954913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704998104 |
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