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Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets

We report a method to detect label-free oligonucleotide targets. The conformation of surface-tethered probe nucleic acids is modulated by alternating electric fields, which cause the molecules to extend away from or fold onto the biased surface. Binding (hybridization) of targets to the single-stran...

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Detalhes bibliográficos
Main Authors: Rant, Ulrich, Arinaga, Kenji, Scherer, Simon, Pringsheim, Erika, Fujita, Shozo, Yokoyama, Naoki, Tornow, Marc, Abstreiter, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077262/
https://ncbi.nlm.nih.gov/pubmed/17951434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703974104
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