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Picosecond fluctuating protein energy landscape mapped by pressure–temperature molecular dynamics simulation

Microscopic statistical pressure fluctuations can, in principle, lead to corresponding fluctuations in the shape of a protein energy landscape. To examine this, nanosecond molecular dynamics simulations of lysozyme are performed covering a range of temperatures and pressures. The well known dynamica...

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Bibliografiske detaljer
Main Authors: Meinhold, Lars, Smith, Jeremy C., Kitao, Akio, Zewail, Ahmed H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077243/
https://ncbi.nlm.nih.gov/pubmed/17956984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708199104
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