Functional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathway.

Streptomyces coelicolor A3(2) and Streptomyces violaceoruber Tü22 produce the antibiotics actinorhodin and granaticin, respectively. Both the aglycone of granaticin and the half-molecule of actinorhodin are derived from one acetyl coenzyme A starter unit and seven malonyl coenzyme A extender units v...

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Bibliografiske detaljer

Udgivet i:	J Bacteriol
Principais autores:	Sherman, D H, Kim, E S, Bibb, M J, Hopwood, D A
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1400167/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.174.19.6184-6190.1992
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