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Carcinogens induce reversion of the mouse pink-eyed unstable mutation

Deletions and other genome rearrangements are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (p(un)) mutation in the mouse is caused by duplication of a 70-kb internal fragment of the p gene. Spontaneous reversion events in homozygous p(un)/p(un) mice occur through d...

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Detalhes bibliográficos
Main Authors: Schiestl, Robert H., Aubrecht, Jiri, Khogali, Fathia, Carls, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20765/
https://ncbi.nlm.nih.gov/pubmed/9114032
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