Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

Mounting evidence suggests that defects in energy metabolism contribute to the pathogenesis of Alzheimer disease (AD). Cytochrome c oxidase (CO) is kinetically abnormal, and its activity is decreased in brain and peripheral tissue in late-onset AD. CO is encoded by both the mitochondrial and the nuc...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Davis, Robert E., Miller, Scott, Herrnstadt, Corinna, Ghosh, Soumitra S., Fahy, Eoin, Shinobu, Leslie A., Galasko, Douglas, Thal, Leon J., Beal, M. Flint, Howell, Neil, Parker, W. Davis
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20756/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9114023/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.9.4526
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