Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and other accessory genes. Although live attenuated HIV vaccines are unlikely to be developed due to a myriad of safet...

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Detalhes bibliográficos
Main Authors: Gorry, Paul R, McPhee, Dale A, Verity, Erin, Dyer, Wayne B, Wesselingh, Steven L, Learmont, Jennifer, Sullivan, John S, Roche, Michael, Zaunders, John J, Gabuzda, Dana, Crowe, Suzanne M, Mills, John, Lewin, Sharon R, Brew, Bruce J, Cunningham, Anthony L, Churchill, Melissa J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075523/
https://ncbi.nlm.nih.gov/pubmed/17888184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-66
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