BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells

Neuronal potassium (K(+)) channels are usually regarded as largely inhibitory, i.e. reducing excitability. Here we show that BK-type calcium-activated K(+) channels enhance high-frequency firing and cause early spike frequency adaptation in neurons. By combining slice electrophysiology and computati...

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Bibliographic Details
Main Authors: Gu, Ning, Vervaeke, Koen, Storm, Johan F
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2007
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075463/
https://ncbi.nlm.nih.gov/pubmed/17303637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.126367
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