Heterologous Production of Dihomo-γ-Linolenic Acid in Saccharomyces cerevisiae

To make dihomo-γ-linolenic acid (DGLA) (20:3n-6) in Saccharomyces cerevisiae, we introduced Kluyveromyces lactis Δ12 fatty acid desaturase, rat Δ6 fatty acid desaturase, and rat elongase genes. Because Fad2p is able to convert the endogenous oleic acid to linoleic acid, this allowed DGLA biosynthesi...

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Main Authors: Yazawa, Hisashi, Iwahashi, Hitoshi, Kamisaka, Yasushi, Kimura, Kazuyoshi, Aki, Tsunehiro, Ono, Kazuhisa, Uemura, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2007
Teme:
Physiology and Biotechnology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074983/
https://ncbi.nlm.nih.gov/pubmed/17873077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01008-07
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