Dissociation of thyrotropin receptor function and thyrotropin dependency in rat thyroid tumour cell lines derived from FRTL-5.

Spontaneously transformed somatic thyrocyte mutants, FRTL-5/TA and FRTL-5/TP, are thyrotropin (TSH) independent for growth and show loss of the thyroid-specific phenotype, with absent thyroglobulin and thyroid peroxidase gene expression. To investigate the role of TSH-receptor (TSH-R) activation in...

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Main Authors: van der Kallen, C. J., Coes, J. H., van Grafhorst, J. P., Schuuring, E. M., Ossendorp, F. A., Thijssen, J. H., Blankenstein, M. A., de Bruin, T. W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074668/
https://ncbi.nlm.nih.gov/pubmed/8761378
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