Effect of transfection of a Drosophila topoisomerase II gene into a human brain tumour cell line intrinsically resistant to etoposide.

The human brain tumour cell line HBT20 is intrinsically resistant to etoposide and does not express mdr-1 mRNA. These studies were conducted to determine whether transfecting a Drosophila (D) topoisomerase II (topo II) gene into HBT20 cells could increase their sensitivity to etoposide. A D-topo II...

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Detalhes bibliográficos
Main Authors: Asano, T., Zwelling, L. A., An, T., McWatters, A., Herzog, C. E., Mayes, J., Loughlin, S. M., Kleinerman, E. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074495/
https://ncbi.nlm.nih.gov/pubmed/8645582
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