Modulation of vinblastine cytotoxicity by dilantin (phenytoin) or the protein phosphatase inhibitor okadaic acid involves the potentiation of anti-mitotic effects and induction of apoptosis in human tumour cells.

Cellular insensitivity to vinca alkaloids is suggested to be primarily due to drug efflux by P-glycoprotein (P-gp). The anti-epileptic phenytoin (DPH), which does not bind to P-gp, can selectively enhance vincristine (VCR) cytotoxicity in wild-type (WT) or multidrug-resistant (MDR) cells. We now dem...

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Hauptverfasser: Kawamura, K. I., Grabowski, D., Weizer, K., Bukowski, R., Ganapathi, R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074306/
https://ncbi.nlm.nih.gov/pubmed/8546904
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