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Modification of endorphin/enkephalin analgesia and stress-induced analgesia by divalent cations, a cation chelator and an ionophore.

The possibility that divalent cations may antagonize opiate peptide analgesia and stress-induced analgesia was examined. Intracerebroventricular injection of low doses of Ca2+, Mn2+ and Mg2+ antagonized beta-endorphin and methionine-enkephalin analgesia. Ba2+ and Cd2+ were without effect. The ionoph...

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Autori principali: Chapman, D. B., Way, E. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1982
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2071602/
https://ncbi.nlm.nih.gov/pubmed/6821193
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