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Active site-directed alkylation of Na+-K+-ATPase by digitalis sulphonate derivatives of different lipophilicity.

1 Sulphonate derivatives of k-strophanthidin and digitoxigenin were tested as active site-directed labels of Na+-K+-adenosine triphosphatase (Na+-ATPase) from guinea-pig heart. 2 Lipophilicity ranged between P = 93 for strophanthidin-3-tosyloxy-acetate (STA) and P = 3028 for digitoxigenin-3-tosyloxy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fricke, U., Klaus, W., Rogatti, M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1981
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2071539/
https://ncbi.nlm.nih.gov/pubmed/6261865
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