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A general purpose RNA-cleaving DNA enzyme

An in vitro selection procedure was used to develop a DNA enzyme that can be made to cleave almost any targeted RNA substrate under simulated physiological conditions. The enzyme is comprised of a catalytic domain of 15 deoxynucleotides, flanked by two substrate-recognition domains of seven to eight...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Santoro, Stephen W., Joyce, Gerald F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20710/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9113977/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.9.4262
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