Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis.

Targeted gene insertion methodology was used to study the effect of perturbing alpha-aminoadipic acid precursor flux on the overall production rate of beta-lactam biosynthesis in Streptomyces clavuligerus. A high-copy-number plasmid containing the lysine epsilon-aminotransferase gene (lat) was const...

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Pubblicato in:	J Bacteriol
Autori principali:	Malmberg, L H, Hu, W S, Sherman, D H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC206817/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8226634/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.175.21.6916-6924.1993
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