Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection

We evaluated the safety and immunogenicity of a chimeric alphavirus vaccine candidate in mice with selective immunodeficiencies. This vaccine candidate was highly attenuated in mice with deficiencies in the B and T cell compartments, as well as in mice with deficient gamma-interferon responsiveness....

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Detalhes bibliográficos
Main Authors: Paessler, Slobodan, Yun, Nadezhda E., Judy, Barbara M., Dziuba, Natallia, Zacks, Michele A., Grund, Anna H., Frolov, Ilya, Campbell, Gerald A., Weaver, Scott C., Estes, D. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2067255/
https://ncbi.nlm.nih.gov/pubmed/17610927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.05.041
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