Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

The endosomal sorting complexes required for transport (ESCRTs) are required to sort integral membrane proteins into intralumenal vesicles of the multivesicular body (MVB). Mutations in the ESCRT-III subunit CHMP2B were recently associated with frontotemporal dementia and amyotrophic lateral scleros...

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Detalhes bibliográficos
Main Authors: Filimonenko, Maria, Stuffers, Susanne, Raiborg, Camilla, Yamamoto, Ai, Malerød, Lene, Fisher, Elizabeth M.C., Isaacs, Adrian, Brech, Andreas, Stenmark, Harald, Simonsen, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064794/
https://ncbi.nlm.nih.gov/pubmed/17984323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200702115
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