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Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
The endosomal sorting complexes required for transport (ESCRTs) are required to sort integral membrane proteins into intralumenal vesicles of the multivesicular body (MVB). Mutations in the ESCRT-III subunit CHMP2B were recently associated with frontotemporal dementia and amyotrophic lateral scleros...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064794/ https://ncbi.nlm.nih.gov/pubmed/17984323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200702115 |
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