Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice

The tumor necrosis factor type 1 death receptor (TNFR1) contributes to apoptosis. TNFR1, a subgroup of the TNFR superfamily, contains a cytoplasmic death domain. We recently demonstrated that the TNFR1 cascade is required for amyloid β protein (Aβ)–induced neuronal death. However, the function of TN...

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Main Authors: He, Ping, Zhong, Zhenyu, Lindholm, Kristina, Berning, Lilian, Lee, Wendy, Lemere, Cynthia, Staufenbiel, Matthias, Li, Rena, Shen, Yong
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2007
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064547/
https://ncbi.nlm.nih.gov/pubmed/17724122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200705042
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