Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells

Rapamycin (rapa)-induced heterodimerization of the FRB domain of the mammalian target of rapa and FKBP12 was used to translocate a phosphoinositide 5-phosphatase (5-ptase) enzyme to the plasma membrane (PM) to evoke rapid changes in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P (2)) levels. Ra...

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Detalhes bibliográficos
Main Authors: Varnai, Peter, Thyagarajan, Baskaran, Rohacs, Tibor, Balla, Tamas
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064515/
https://ncbi.nlm.nih.gov/pubmed/17088424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200607116
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