TGF-β signaling is essential for joint morphogenesis

Despite its clinical significance, joint morphogenesis is still an obscure process. In this study, we determine the role of transforming growth factor β (TGF-β) signaling in mice lacking the TGF-β type II receptor gene (Tgfbr2) in their limbs (Tgfbr2(PRX-1KO)). In Tgfbr2(PRX-1KO) mice, the loss of T...

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Detalhes bibliográficos
Main Authors: Spagnoli, Anna, O'Rear, Lynda, Chandler, Ronald L., Granero-Molto, Froilan, Mortlock, Douglas P., Gorska, Agnieszka E., Weis, Jared A., Longobardi, Lara, Chytil, Anna, Shimer, Kimberly, Moses, Harold L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064369/
https://ncbi.nlm.nih.gov/pubmed/17576802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200611031
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