Dynamic recruitment of phospholipase Cγ at transiently immobilized GPI-anchored receptor clusters induces IP(3)–Ca(2+) signaling: single-molecule tracking study 2

Clusters of CD59, a glycosylphosphatidylinositol-anchored receptor (GPI-AR), with physiological sizes of approximately six CD59 molecules, recruit Gαi2 and Lyn via protein–protein and raft interactions. Lyn is activated probably by the Gαi2 binding in the same CD59 cluster, inducing the CD59 cluster...

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Autores principales: Suzuki, Kenichi G.N., Fujiwara, Takahiro K., Edidin, Michael, Kusumi, Akihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2007
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064217/
https://ncbi.nlm.nih.gov/pubmed/17517965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200609175
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