Dynamic recruitment of phospholipase Cγ at transiently immobilized GPI-anchored receptor clusters induces IP(3)–Ca(2+) signaling: single-molecule tracking study 2

Clusters of CD59, a glycosylphosphatidylinositol-anchored receptor (GPI-AR), with physiological sizes of approximately six CD59 molecules, recruit Gαi2 and Lyn via protein–protein and raft interactions. Lyn is activated probably by the Gαi2 binding in the same CD59 cluster, inducing the CD59 cluster...

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Bibliografiska uppgifter
Huvudupphovsmän: Suzuki, Kenichi G.N., Fujiwara, Takahiro K., Edidin, Michael, Kusumi, Akihiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2007
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064217/
https://ncbi.nlm.nih.gov/pubmed/17517965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200609175
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