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Notch signaling is necessary for epithelial growth arrest by TGF-β
Transforming growth factor β (TGF-β) and Notch act as tumor suppressors by inhibiting epithelial cell proliferation. TGF-β additionally promotes tumor invasiveness and metastasis, whereas Notch supports oncogenic growth. We demonstrate that TGF-β and ectopic Notch1 receptor cooperatively arrest epit...
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| Asıl Yazarlar: | , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064026/ https://ncbi.nlm.nih.gov/pubmed/17325209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200612129 |
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