Notch signaling is necessary for epithelial growth arrest by TGF-β

Transforming growth factor β (TGF-β) and Notch act as tumor suppressors by inhibiting epithelial cell proliferation. TGF-β additionally promotes tumor invasiveness and metastasis, whereas Notch supports oncogenic growth. We demonstrate that TGF-β and ectopic Notch1 receptor cooperatively arrest epit...

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Bibliographic Details
Main Authors: Niimi, Hideki, Pardali, Katerina, Vanlandewijck, Michael, Heldin, Carl-Henrik, Moustakas, Aristidis
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064026/
https://ncbi.nlm.nih.gov/pubmed/17325209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200612129
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